程黎明的概述

1. 程黎明的概述

程黎明教授提出并始终坚持“微创化手术、全过程康复、精细化护理”的现代脊柱外科理念，一切以病人需求为中心，构建了“外科与康复一体化”的国际领先脊柱专科模式。为脊柱脊髓损伤的病患提供高水平“伤椎置钉、伤椎增强”等新技术，给所有病人提供全过程康复。 全面开展国内领先的“显微颈椎前路手术、可扩张通道/固定通道下MIS-TLIF、经皮内镜椎间盘手术、经皮椎弓根螺钉胸腰椎骨折复位术、老年骨质疏松性骨折PKP术”等系列脊柱微创手术。科室提供专业化脊柱脊髓康复和人性化优质护理服务，获得了来自全国各地患者的好评。 先后入选2002年“上海市医苑新星”、2006年“教育部新世纪优秀人才支持计划”、2012年“上海市优秀学科带头人计划”、2013年“上海市卫生局新百人计划”、2015年“国家级百千万人才工程国家级人选 ”、“国家有突出贡献中青年专家”、“上海市领军人才”等人才培养计划； 主持国际科技合作项目、国家自然科学基金重点项目等16项，科研经费达千万元。发表论文100余篇，其中《Cell》、《Nature Medicine》、《Nature》、《Cell Stem Cell》等SCI、EI收录论文30余篇，中华期刊30余篇；主编著作2部，参编著作8部。获得上海市科技进步奖一、二等奖、上海市医学科技奖一、三等奖、上海市优秀发明选拔赛金奖、军队临床医疗成果奖等10余项省部级奖励。

2. 程黎明的介绍

程黎明，安徽桐城市人，医学博士，主任医师，教授，博士生导师。现任同济大学附属同济医院副院长、医学科学研究所所长；大外科主任、骨科主任、脊柱外科主任、同济大学脊柱脊髓损伤研究所所长。在脊柱脊髓损伤综合治疗、重度颈椎病、复杂椎管狭窄等脊柱疾病微创手术治疗方面独具特色。

3. 程黎明的主要文章

（*为通讯作者，#共同第一作者）1.Luo YP#, Coskun V#, Liang AB#, YuJH#, Cheng LM#, GeWH#, ShiZP, ZhangKS, LiC, CuiY, LinHJ, LuoDD, WangJB,LinC, DaiZ, ZhuHW, ZhangJ, LiuJ, Liu HL, Jde Velis J,Horvath S,Sun YE*and LiSG*.Single-Cell Transcriptome Analyses Reveal Signalsto Activate Dormant Neural StemCells. Cell, 2015; 161(5):1175-1186. 2.Cui X,Chen L,Xue T,Yu J,Liu J,Ji Y,Cheng LM*.Human umbilical cord and dental pulp-derived mesenchymal stem cells: Biological characteristics and potential roles invitro and invivo. Mol Med Rep. 2015;11(5):3269-78. 3.Li YF, Tang XZ, Liang CG,Hui YM,Ji YH,Xu W,Qiu W, Cheng LM*.Role of growth differentiation factor-5 and bone morphogenetic protein type II receptor in the development of lumbar intervertebral disc degeneration. Int J Clin Exp Pathol.2015;8(1):719-726. 4.Wang M,Cheng LM*,Li QB, Chen ZW and Wang SL*.Two-dimensionalnanosheetsassociated with one-dimensional single-crystalline nanorods self-assembled into three-dimensional flower-like Mn3O4 hierarchical architectures.Phys.Chem.Chem.Phys,2014,16(39),21742-21746. 5.Zhang ZT, Song MK, Liu X, Kang SS, Kwon Il-Sun, Duong DM, Seyfried NT, Hu WT, Liu ZX, Wang JZ, Cheng LM*, Sun YE, Yu SP, Levey AI & Ye KQ*.Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease. Nature medicine, 2014;20(11):1254-1262. 6.Wu ZR, Zhao ZR, Yu Y, Hu X, Xu W, Zeng ZL, Sun E, Cheng LM*. New strategies for the repair of spinal cord injury. Chin. Sci. Bull.,2014; 59(31): 4041-4049. 7.Chen L, Cui XY, Wu ZR, Jia L, Yu Y, Zhou QL, Hu X, Xu W, Luo DD , Liu J, Xiao JJ, Yan Q, Cheng LM*. Transplantation of bone marrow mesenchymal stem cells pretreated with valproic acid in rats with an acute spinal cord injury. BioScience Trends, 2014;8(2P): 111-119. 8.Liu HL, Chen YC, Niu YY, Zhang KS, Kang Y, Ge WH, Liu X, Zhao EF, Wang CC, Lin SY, Jing B, Si CY, Lin Q, Chen XY, Lin HJ, Pu XQ, Wang YY, Qin BL, Wang F, Wang H, Si W, Zhou J, Tan T, Li TQ, Ji SH, Xue ZG, Luo YP, Cheng LM, Zhou Q, Li SG, Sun YE*, Ji WZ*. TALEN-Mediated Gene Mutagenesis in Rhesus and Cynomolgus Monkeys. Cell Stem Cell. 2014, 14(3):323-328. 9.Jin LJ, Wu ZR, Xu W, Hu X, Zhang J, Xue ZG*, Cheng LM*. Identifying gene expression profile of spinal cord injury in rat by bioinformatics strategy. Mol Biol Rep, 2014, 41(5):3169-77. 10.Yu Y, Zhu R, Zeng ZL, Jia YW, Wu ZR, Ren YL, Chen B, Ding ZQ, Cheng LM*.The strain at bone-implant interface determines the effect of spinopelvic reconstruction following total sacrectomy: a strain gauge analysis in various spinopelvic constructs. PLoS One, 2014,9(1):e85298. 11. Xue ZG*, Huang K, Cai CC, Cai LB, Jiang CY, Feng Y, Liu ZS, Zeng Q, Cheng LM, Sun YE, Liu JY*, Horath S and Fan GP*. Genetic Programs in Human and Mouse Early Embryos Revealed by Sigle-Cell RNA-Sequenciong. Nature, 2013, 500,593–597. 12.Cheng LM*, Wang JJ, Zeng ZL, Zhu R, Yu Y, Li C, Wu ZR Pedicle screw fixation for traumatic fractures of the thoracic and lumbar spine (review). Cochrane Database of Systematic Reviews .2013, May, 31; 5:CD009073. 13.Zhang J*, Zhang J, Zhou Y, Wu YJ, Kang X, Ma L, Liu LH, Li MJ, Shao ZH, Cheng LM*, Yu L. Novel cerebellum-enriched miR-592 may play a role in neural progenitor cell differentiation and neuronal maturation through regulating lrrc4c and nfasc in rat. Current molecular medicine, 2013; 13(9):1432-45. 14. Cui X, Chen L, Ren YL, Ji Y, Liu W, Liu J, Yan Q, Cheng LM, Sun YE. Genetic modification of mesenchymal stem cells in spinal cord injury repair strategies. Biosci Trends. 2013;7(5):202-208. 15.Zeng ZL, Zhu R, Li SZ, Yu Y, Wang JJ, Jia YW, Chen B, Cheng LM*. Formative mechanism of intracanal fracture fragments in thoracolumbar burst fractures: a finite element study. Chin Med J. 2013;126 (15):2852-2858. 16. Wu ZR; Huang K, Yu J, Le T, Namihira M, LiuYP, Zhang, Jun, Xue ZG, Cheng LM*, Fan GP*. Dnmt3a regulates both cell proliferation and differentiation of mouse neural stem cells. Journal of Neuroscience Research 2012; 90(10):1883-91. 17. Zhu R, Cheng LM*, Yu Y, Zander T, Chen B, Rohlmann A. Comparison of four reconstruction methods after total sacrectomy: a finite element study. Clinical Biomechanics. 2012; 27(8):771-776. 18.Cheng LM*, Yu Y, Zhu R, Lv HX, Jia YW, Zeng ZL, Chen B, Ding ZQ. Structural stability of different reconstruction techniques following total sacrectomy: a biomechanical study. Clinical Biomechanics 2011; 26(10): 977-981. 19. JIA YW, CHENG LM*, YU GR, DU CF, YANG ZY, YU Y and DING ZQ.A finite element analysis of the pelvic reconstruction using fibular transplantation fixed with four different rod-screw systems after typeresection I. Chinese Medical Journal 2008; 121(4):321-326. 20.Lv HX,Cheng LM*, Yu Y, Jia YW. Digital marker tracing combined with center-of-mass algorithm in analyzing viscoelasticity characteristicof lumbosacroiliac complex. 3st International Conference on Bioinformatics and Biomedical Engineering, ICBBE, 2009，1156. 21.Yu Y, Cheng LM*, Zhu R, Lv HX, Jia YW, Zeng ZL, Yu GR. The stability analysis of different reconstruction methods after total sacrectomy.3st International Conference on Bioinformatics and Biomedical Engineering, ICBBE, 2009，1-4. 22.Zhu R, Cheng LM*, Yu Y, Lv HX, Jia YW, Zeng ZL. Development and validation of a three-dimensional finite element model of lumbo-pelvic-femoral complex.3st International Conference on Bioinformatics and Biomedical Engineering, ICBBE, 2009:1-4. 23.Cheng LM*,Jia YW, Yu GR, Yu Y, Yang ZY, Lou YJ, Ni M. Strain analysis of pelvis after iliac bone tumor resection，2st International Conference on Bioinformatics and Biomedical Engineering, ICBBE, 2008，1185-1188. 24.Jia YW, Cheng LM*, Yu GR, Yu Y, Lou YJ, Yang ZY, Ni M. Stability Analysis of the Pelvis after Type Ⅰ Resection of Iliac Tumor. 2st International Conference on Bioinformatics and Biomedical Engineerin g, ICBBE, 2008，1836-1839. 25.Jia YW, Cheng LM*, Yu GR, Lou YJ, Yu Y, Chen B,Ding ZQ. Finite element analysis of pelvic reconstruction using fibular transplantation fixed with rod-screw system after type I resection. 1st International Conference on Bioinformatics and Biomedical Engineering, ICBBE, 2007,430-433. 26.Jia YW, Cheng LM*, Yu GR, Lou YJ. Digital image measurement of specimen deformation based on CCD cameras and Image J software: an application to human pelvic biomechanics. Proc.of SPIE, 2007; 6837 04:1-10.

4. 程黎明的获奖项目

1.上海市科技进步奖一等奖（第一完成人）  (2014.09) 项目名称：脊柱脊髓损伤修复重建相关生物力学及生物学研究与临床应用 2.上海市医学科技奖一等奖（第一完成人）  (2014.04) 项目名称：脊柱脊髓损伤修复重建的临床及相关基础研究 3.第26届上海市优秀发明选拔赛金奖（第一完成人）  (2014.03) 项目名称：脊柱矫形固定与功能测试系列装置研发 4.上海市科技进步奖二等奖（第一完成人）  (2008.10) 项目名称：骨盆肿瘤切除重建的生物力学和临床研究